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Long COVID: Diagnosis & Management for Clinicians | Noah Greenspan, DPT

March 9, 2026 Ananya Mittal - World Editor

The lingering effects of COVID-19, often referred to as Long COVID, continue to pose a significant challenge for healthcare providers and patients alike. Millions worldwide are experiencing symptoms months, even years, after the initial infection, and navigating diagnosis and treatment remains complex. Noah Greenspan, DPT, a leading expert in cardiopulmonary and complex medical rehabilitation, has been at the forefront of understanding and addressing these persistent issues. His work, particularly in pioneering both in-person and virtual recovery programs, offers valuable insights into managing this evolving condition.

Understanding the Complexity of Long COVID

Long COVID, or post-COVID condition, isn’t a single illness but rather a constellation of symptoms that can vary widely from person to person. These symptoms can range from fatigue and shortness of breath to cognitive dysfunction (“brain fog”), muscle aches, and even heart-related issues. The lack of a definitive diagnostic test and the overlap with other conditions, like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), contribute to the diagnostic challenges. Dr. Greenspan’s experience highlights the need for a comprehensive approach to assessment and rehabilitation. He serves as the director of the Pulmonary Wellness & Rehabilitation Complex in New York City and founder of the Pulmonary Wellness Foundation, dedicating his career to helping patients regain their quality of life after cardiovascular, pulmonary, and complex medical challenges, including Long COVID.

Diagnostic Hurdles and Emerging Criteria

Pinpointing Long COVID is challenging since there isn’t a single biomarker or test to confirm its presence. Diagnosis often relies on a patient’s reported symptoms and ruling out other potential causes. Dr. Greenspan’s insights, as discussed in an interview with Infection Control Today, emphasize the evolving understanding of diagnostic criteria. The condition’s parallels with ME/CFS further complicate matters, as both share overlapping symptoms like profound fatigue and post-exertional malaise. This overlap underscores the need for clinicians to consider a broad differential diagnosis and avoid attributing all symptoms solely to a previous COVID-19 infection.

Rehabilitation Strategies: Pacing and Beyond

Effective management of Long COVID often involves a multidisciplinary approach, focusing on symptom management and functional restoration. A key strategy championed by Dr. Greenspan is “pacing,” a technique where individuals learn to balance activity and rest to avoid exacerbating symptoms. This isn’t simply about resting more; it’s about strategically managing energy expenditure to stay within one’s physiological limits. Other strategies include addressing specific symptoms like shortness of breath through pulmonary rehabilitation exercises and optimizing hydration and electrolyte balance. As noted in an interview on Standing Up to POTS, Dr. Greenspan has also observed anecdotal evidence suggesting potential benefits from certain oxygen therapies, though further research is needed to confirm these findings.

The Connection to POTS and Autonomic Dysfunction

Interestingly, Dr. Greenspan was among the first to recognize a link between Long COVID and Postural Orthostatic Tachycardia Syndrome (POTS), a condition affecting blood flow and often causing dizziness, fatigue, and palpitations. His early observations in New York City, at the epicenter of the initial pandemic wave, were crucial in identifying this connection. The Standing Up to POTS podcast features a detailed discussion with Dr. Greenspan on this relationship, highlighting the importance of recognizing autonomic dysfunction in Long COVID patients. POTS is characterized by an abnormal increase in heart rate upon standing, and its co-occurrence with Long COVID suggests a potential underlying mechanism involving the autonomic nervous system.

Research Gaps and the Need for Awareness

Despite growing awareness, significant research gaps remain in understanding Long COVID. The long-term impact of the condition, its underlying causes, and the most effective treatment strategies are still being investigated. Dr. Greenspan emphasizes the critical need for increased research funding and awareness within the medical community. AJMC reports on his insights into these challenges, noting the difficulties in diagnosing the condition and the importance of individualized treatment plans. Further research is needed to identify biomarkers, develop targeted therapies, and improve the quality of life for those living with Long COVID.

What Comes Next: Ongoing Investigation and Refined Approaches

The path forward for Long COVID care involves continued research, improved diagnostic tools, and refined rehabilitation strategies. Ongoing clinical trials are investigating potential treatments, including antiviral medications, immunomodulatory therapies, and targeted rehabilitation programs. Public health surveillance systems are also being utilized to track the prevalence and long-term effects of Long COVID, informing public health guidance and resource allocation. Clinicians are encouraged to stay updated on the latest research and guidelines, and to adopt a patient-centered approach that considers the individual needs and symptoms of each person affected by this complex condition. The Pulmonary Wellness Foundation, founded by Dr. Greenspan, continues to be a valuable resource for patients and healthcare professionals seeking information and support. Infection Control Today highlights the ongoing fight for recognition and resources in the medical community, emphasizing the importance of continued advocacy and collaboration to address this persistent health challenge.

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