Anti-Sagging Trend: New PCL Collagen Stimulator GOURI Rebuilds Skin Foundation | DEXLEVO

The global medical aesthetics market is undergoing a significant shift, moving beyond temporary fixes for visible signs of aging toward treatments that address the underlying structural causes of skin laxity. This “Anti-Sagging” paradigm, as industry experts are calling it, prioritizes rebuilding the skin’s foundation – specifically, boosting collagen production within the dermal layer – rather than simply filling wrinkles or restoring volume. This evolution is driving increased interest in biostimulators and particularly in Polycaprolactone (PCL), a biodegradable polymer gaining traction for its ability to stimulate long-term collagen synthesis.

The Rise of Neocollagenesis and PCL

For years, Hyaluronic Acid (HA) fillers and neurotoxins have dominated the aesthetic market, offering immediate but often temporary results. However, a growing understanding of the aging process has revealed that these approaches treat symptoms, not the root cause. The focus is now shifting to neocollagenesis – the stimulation of new collagen synthesis – to restore the skin’s structural integrity. PCL is emerging as a key player in this movement due to its unique properties. Unlike HA, which primarily provides hydration and volume, PCL acts as a scaffold, encouraging the body to produce its own collagen over time. This leads to a more natural and sustainable improvement in skin elasticity and firmness.

DEXLEVO’s GOURI: A Liquid PCL Innovation

Amidst this evolving landscape, DEXLEVO’s liquid PCL collagen stimulator, ‘GOURI,’ is attracting considerable attention. What sets GOURI apart is its formulation based on the company’s proprietary CESABP (Collagenesis-Enabled Solubilized Active and Biodegradable Polymer) technology. Crucially, GOURI is entirely free of microparticles, a characteristic that significantly impacts its performance and safety profile. Traditional PCL formulations often involve microparticles suspended in a carrier gel, which can sometimes lead to uneven distribution and localized reactions.

The absence of microparticles in GOURI allows for superior spreadability. Upon injection, the liquid PCL disperses evenly throughout the dermal layer, promoting uniform collagen regeneration and elasticity improvement across the entire treated area. This contrasts with particle-based fillers, which tend to remain localized at the injection site. The goal is a comprehensive rejuvenation, rather than isolated corrections.

Clinical Data and the “Triple Effect”

Recent presentations at industry conferences, such as the IMCAS World Congress 2026 in Paris, have highlighted the clinical efficacy of GOURI. Dr. Seung-min Oh, Chief Director of O& Clinic and Academic Chair of the Korean Association of Laser, Dermatology, and Trichology, presented data demonstrating a “triple effect” – redness reduction, skin texture improvement, and volume formation – achieved through precise injection techniques tailored to facial anatomy.¹ This data suggests that GOURI’s uniform distribution and collagen-stimulating properties translate into visible improvements across multiple aspects of skin quality.

“Thanks to the unique spreadability of the fully liquid type PCL, GOURI can induce natural collagen regeneration across the entire face,” Dr. Oh stated, as reported by Medisobija News. “By precisely leveraging this spreadability with a deep understanding of anatomical structures, we can provide patients with the most natural and healthy results. It is time for ‘Precision Aesthetics,’ rooted in clinical data, to become the universal standard.”²

Beyond Facial Aesthetics: The Broader Implications

While the initial focus is on facial rejuvenation, the potential applications of liquid PCL technology extend beyond aesthetics. The ability to stimulate collagen production could have implications for treating skin laxity in other areas of the body, such as the neck, décolletage, and hands. Research is ongoing to explore the use of PCL in scar revision and wound healing, leveraging its biocompatibility and collagen-inducing properties. The Korean beauty boom, which has drawn increased numbers of Chinese tourists to Seoul seeking advanced dermatological treatments, as reported by AzerNews, may further accelerate the adoption of these innovative technologies.

What Comes Next: Establishing Standards and Expanding Research

The emergence of liquid PCL as a significant force in the medical aesthetics market is still relatively recent. A key next step will be the establishment of standardized protocols for injection techniques and treatment parameters. Dr. Oh’s emphasis on “Precision Aesthetics” underscores the importance of a thorough understanding of facial anatomy and individualized treatment plans. Further research is too needed to fully elucidate the long-term effects of liquid PCL and to optimize treatment protocols for different skin types and concerns. Continued clinical trials and data collection will be crucial for solidifying the evidence base and ensuring patient safety and satisfaction. DEXLEVO, as the developer of the first fully liquid PCL-based collagen stimulator, is positioned to play a leading role in driving these advancements and shaping the future of the Anti-Sagging movement.

References

¹ IMCAS World Congress 2026. GOURI Symposium. Presented at: IMCAS World Congress 2026; January 31, 2026; Paris, France.

² Medisobija News. Dr. Seung-min Oh proves precision medical value of liquid PCL GOURI at IMCAS Paris 2026. Published February 5, 2026. Accessed March 13, 2026. https://www.medisobizanews.com/news/articleView.html?idxno=134310